DOI: 10.62796/pijst.2024v1i7004

  DOI URL: https://doi.org/10.62796/pijst.2024v1i7004

Abstract- The increasing prevalence of chronic conditions has led to a rise in long-term prescription drug use, necessitating a comprehensive understanding of its impact on physical health. This review explores the common side effects associated with prolonged use of medications, focusing on key drug classes such as antihypertensive, statins, antidepressants, and antidiabetics. The mechanisms underlying druginduced side effects, including cumulative toxicity and delayed-onset reactions, are examined in detail. Factors influencing the severity and likelihood of adverse effects, such as dosage, duration, age, genetics, and co morbidities, are analyzed. The role of pharmacogenomics in predicting and managing side effects is highlighted, emphasizing the need for personalized medicine approaches. The paper further discusses the significant impact of long-term drug side effects on patients’ quality of life and medication adherence. Common side effects, including cardiovascular, gastrointestinal, and neurological symptoms, are analyzed, with case studies illustrating real-world implications. Strategies for mitigating these effects, both pharmaceutical and non-pharmaceutical, are explored, alongside the critical role of patient education and regular monitoring. The importance of pharmacist interventions in optimizing therapy and reducing adverse reactions is emphasized.